CXCL7
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Protein asas pro-plateletn (kemokina (motif C-X-C) ligand 7)
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| Lakaran PDB berdasarkan 1f9p. | ||||||||||||||
| Struktur sedia ada: 1f9p, 1nap, 1tvx | ||||||||||||||
| Pengecam | ||||||||||||||
| Simbol | PPBP; PBP; B-TG1; Beta-TG; CTAP-III; CTAP3; CTAPIII; CXCL7; LA-PF4; LDGF; MDGF; NAP-2; SCYB7; TC1; TC2; TGB; TGB1; THBGB; THBGB1 | |||||||||||||
| ID luar | OMIM: 121010 MGI: 1888712 HomoloGene: 48122 | |||||||||||||
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| Pola pernyataan RNA | ||||||||||||||
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| Ortolog | ||||||||||||||
| Manusia | Tikus | |||||||||||||
| Entrez | 5473 | 57349 | ||||||||||||
| Ensembl | ENSG00000163736 | ENSMUSG00000029372 | ||||||||||||
| Uniprot | P02775 | n/a | ||||||||||||
| Refseq | NM_002704 (mRNA) NP_002695 (protein) |
NM_023785 (mRNA) NP_076274 (protein) |
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| Lokasi | Chr 4: 75.07 - 75.07 Mb | Chr 5: 91.84 - 91.85 Mb | ||||||||||||
| Gelintaran Pubmed | [1] | [2] | ||||||||||||
Kemokina (motif C-X-C motif) ligand 7 (CXCL7) ialah gen manusia.[1] Protein terkod itu ialah sitokina kecil yang tergolong dalam keluarga kemokina CXC dan merupakan salah satu isobentuk protein Beta-Tromboglobulin atau protein asas pro-platelet (PPBP).[2]
CXCL7 ialah protein yang dibebaskan pada jumlah yang besar oleh platelet, selepas pengaktifannya.[3] Ia merangsangkan berbagai-bagai proses, termasuk: [4][5]
- mitogenesis;
- metabolisme glukosa;
- sintesis matriks luar sel; dan
- sinthesis pengaktif plasminogen.
Rujukan [sunting]
- ↑ "Entrez Gene: PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5473.
- ↑ Hristov M, Zernecke A, Bidzhekov K, et al. (March 2007). "Importance of CXC chemokine receptor 2 in the homing of human peripheral blood endothelial progenitor cells to sites of arterial injury". Circ. Res. 100 (4): 590–7. doi:10.1161/01.RES.0000259043.42571.68. PMID 17272812.
- ↑ Majumdar S, Gonder D, Koutsis B, Poncz M (1991). "Characterization of the human beta-thromboglobulin gene. Comparison with the gene for platelet factor 4". J Biol Chem 266 (9): 5785–9. PMID 1826003.
- ↑ Castor C, Miller J, Walz D (1983). "Structural and biological characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor". Proc Natl Acad Sci USA 80 (3): 765–9. doi:10.1073/pnas.80.3.765. PMID 6572368.
- ↑ Castor C, Furlong A, Carter-Su C (1985). "Connective tissue activation: stimulation of glucose transport by connective tissue activating peptide III". Biochemistry 24 (7): 1762–7. doi:10.1021/bi00328a029. PMID 4005226.
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