Serotonin

Serotonin
Nama
	Nama IUPAC 5-Hidroksitriptamina
	Nama IUPAC pilihan 3-(2-Aminoetil)-1H-indol-5-ol
	Nama lain 5-HT, 5-Hidroksitriptamina, Enteramina, Trombositin, 3-(β-Aminoetil)-5-hidroksiindol, Trombotonin
Pengecam
No. Pendaftaran CAS	50-67-9 ;
Imej model 3D Jmol	Imej berinteraktif;
ChEBI	CHEBI:28790 ;
ChEMBL	ChEMBL39 ;
ChemSpider	5013 ;
ECHA InfoCard	100.000.054
IUPHAR/BPS	5;
KEGG	C00780 ;
MeSH	Serotonin
PubChem CID	5202;
UNII	333DO1RDJY ;
CompTox Dashboard (EPA)	DTXSID8075330 ;
	InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2 Key: QZAYGJVTTNCVMB-UHFFFAOYSA-N ; InChI=1/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2 Key: QZAYGJVTTNCVMB-UHFFFAOYAX;
	SMILES C1=CC2=C(C=C1O)C(=CN2)CCN;
Sifat
Formula kimia	C10H12N2O
Jisim molar	176.215 g/mol
Rupa bentuk	Serbuk putih
Takat lebur	167.7 °C (333.9 °F; 440.8 K) 121–122 °C (ligroin)
Takat didih	416 ± 30 °C (pada 760 Torr)
Keterlarutan dalam air	Sedikit larut
Keasidan (pKa)	10.16 dalam air pada 23.5 °C
Momen dwikutub	2.98 D
Bahaya
MSDS	External MSDS
	Dos maut (LD) atau kepekatan dos maut (LC)
LD50 (median dos)	750 mg/kg (subkutaneus, tikus), 4500 mg/kg (intraperitoneal, tikus), 60 mg/kg (oral, tikus)
	Kecuali jika dinyatakan sebaliknya, data diberikan untuk bahan-bahan dalam keadaan piawainya (pada 25 °C [77 °F], 100 kPa).
	pengesahan (apa yang perlu: /?)
	Rujukan kotak info

Serotonin
Data klinikal
Nama lain	5-HT, 5-Hidroksitriptamina, Enteramina, Trombositin, 3-(β-Aminoetil)-5-hidroksiindol, Trombotonin
Data fisiologi
Sumber tisu	Nukleus rafe, sel enterokromafin
Tisu sasaran	Seluruh sistem
Reseptor	5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, 5-HT7
Agonis	Tak terus: SSRI, MAOI
Pelopor	5-HTP
Biosintesis	Dekarboksilase asid L-amino aromatik
Metabolisme	MAO
Pengecam
	Nama IUPAC 3-(2-Aminoetil)-1H-indola-5-ol;
Nombor CAS	50-67-9;
PubChem CID	5202;
IUPHAR/BPS	5;
ChemSpider	5013;
KEGG	C00780;
Ligan PDB	SRO (PDBe, RCSB PDB);
CompTox Dashboard (EPA)	DTXSID8075330 ;
ECHA InfoCard	100.000.054

Serotonin (5-hidroksitriptamina; 5-HT) ialah suatu pengutus saraf monoamino yang disintesiskan pada neuron-neuron serotonergis dalam sistem saraf pusat dan sel-sel enterokromafin dalam saluran pencernaan. Hormon ini dipercaya sebagai pemberi perasaan selesa dan senang.^[6]

Rujukan[sunting | sunting sumber]

^ Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 (©1994–2011 ACD/Labs)
^ Mazák K, Dóczy V, Kökösi J, Noszál B (April 2009). "Proton speciation and microspeciation of serotonin and 5-hydroxytryptophan". Chemistry & Biodiversity. 6 (4): 578–590. doi:10.1002/cbdv.200800087. PMID 19353542. S2CID 20543931.
^ Pietra S (1958). "[Indolic derivatives. II. A new way to synthesize serotonin]". Il Farmaco; Edizione Scientifica (dalam bahasa Itali). 13 (1): 75–79. PMID 13524273.
^ Erspamer V (1952). "Ricerche preliminari sulle indolalchilamine e sulle fenilalchilamine degli estratti di pelle di Anfibio". Ricerca Scientifica. 22: 694–702.
^ Tammisto T (1967). "Increased toxicity of 5-hydroxytryptamine by ethanol in rats and mice". Annales Medicinae Experimentalis et Biologiae Fenniae. 46 (3): 382–384. PMID 5734241.
^ Young SN (2007). "How to increase serotonin in the human brain without drugs". Rev. Psychiatr. Neurosci. 32 (6): 394–99. PMID 18043762.

Pautan luar[sunting | sunting sumber]

Tapak Dr. P.K. Gillman, 'PsychoTropicalResearch', yang seluruhnya membincangkan kajian Serotonin dan 'Sindroma Serotonin'.
Molekul bulan ini: Serotonin
((Indonesia)) Naik Neurotransmitter Serotonin Otak Pemangkin Kelakuan Pencerobohan

[CAPLUS-1] Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 (©1994–2011 ACD/Labs)

[pK-2] Mazák K, Dóczy V, Kökösi J, Noszál B (April 2009). "Proton speciation and microspeciation of serotonin and 5-hydroxytryptophan". Chemistry & Biodiversity. 6 (4): 578–590. doi:10.1002/cbdv.200800087. PMID 19353542. S2CID 20543931.

[MP-3] Pietra S (1958). "[Indolic derivatives. II. A new way to synthesize serotonin]". Il Farmaco; Edizione Scientifica (dalam bahasa Itali). 13 (1): 75–79. PMID 13524273.

[rat2-4] Erspamer V (1952). "Ricerche preliminari sulle indolalchilamine e sulle fenilalchilamine degli estratti di pelle di Anfibio". Ricerca Scientifica. 22: 694–702.

[rat-5] Tammisto T (1967). "Increased toxicity of 5-hydroxytryptamine by ethanol in rats and mice". Annales Medicinae Experimentalis et Biologiae Fenniae. 46 (3): 382–384. PMID 5734241.

[6] Young SN (2007). "How to increase serotonin in the human brain without drugs". Rev. Psychiatr. Neurosci. 32 (6): 394–99. PMID 18043762.

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