Vasopresin

AVP
Pengecam
Alias	AVP, ADH, ARVP, AVP-NPII, AVRP, VP, arginine vasopressin, Vasopressin
Pengecam-pengecam luaran	OMIM: 192340 MGI: 88121 HomoloGene: 417 GeneCards: AVP
Kedudukan gen (Manusia)
Kr.	Kromosom 20
Tamat	3,084,724 bp
Corak ekspresi RNA
	Top expressed in
	Hipotalamus; ; internal globus pallidus; ; gastric mucosa; ; buah pinggang; ; monocyte; ; amygdala; ; Pituitari anterior; ; subcutaneous adipose tissue; ; substantia nigra; ; left adrenal gland;
	Top expressed in
	paraventricular nucleus of hypothalamus; ; supraoptic nucleus; ; arcuate nucleus; ; optic nerve; ; median eminence; ; suprachiasmatic nucleus; ; ventromedial nucleus; ; lateral hypothalamus; ; Lensa; ; lidah;
	More reference expression data
	Rujukan lanjutan untuk data ekspresi
Ontologi gen
Fungsi molekul	protein kinase activity; hormone activity; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; neurohypophyseal hormone activity; signaling receptor binding; V1A vasopressin receptor binding; V1B vasopressin receptor binding; neuropeptide hormone activity;
Komponen sel	extracellular region; cytosol; clathrin-coated vesicle membrane; Ekstrasel; secretory granule; Dendrit;
Proses biologi	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; Pencerutan pembuluh darah; negative regulation of release of cytochrome c from mitochondria; ERK1 and ERK2 cascade; water transport; cell-cell signaling; negative regulation of apoptotic process; protein kinase C signaling; generation of precursor metabolites and energy; positive regulation of peptidyl-serine phosphorylation; positive regulation of gene expression; renal water homeostasis; Transduksi isyarat; proses apoptosis; membrane organization; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway; maternal aggressive behavior; positive regulation of systemic arterial blood pressure; positive regulation of cytosolic calcium ion concentration; negative regulation of female receptivity; grooming behavior; locomotory behavior; positive regulation of cell population proliferation; positive regulation of glutamate secretion; response to organic cyclic compound; positive regulation of cell growth; positive regulation of prostaglandin biosynthetic process; positive regulation of cellular pH reduction; response to testosterone; response to nicotine; tingkah laku organisma sosial; regulation of renal sodium excretion; hyperosmotic salinity response; maternal behavior; penile erection; response to ethanol; positive regulation of vasoconstriction; multicellular organismal water homeostasis; negative regulation of transmission of nerve impulse;
	Sumber:Amigo / QuickGO
Ortolog
	551
	11998
	ENSG00000101200
	ENSMUSG00000037727
	P01185
	P35455
	NM_000490
	NM_009732
	NP_000481
	NP_033862
	Wikidata
Papar/Sunting data manusia	Papar/Sunting data mencit

Vasopresin
Data klinikal
Sebutan	/ˌveɪzoʊˈprɛsɪn/
Nama lain	Hormon antidiuretik (ADH); vasopresin arginina (AVP); argipresin
Kod ATC	H01BA01 (WHO) ;
Data fisiologi
Sumber tisu	Nukleus supraoptik; Nukleus paraventrikular hipotalamus
Tisu sasaran	Seluruh sistem
Reseptor	V1A, V1B, V2, OXTR
Agonis	Felipresin, desmopresin
Antagonis	Diuretik
Metabolisme	Secara utamanya di hati dan ginjal
Data farmakokinetik
Pengikatan protein	1%
Metabolisme	Secara utamanya di hati dan ginjal
Penyingkiran separuh hayat	10–20 minit
Perkumuhan	Urin
Pengecam
	Nama IUPAC 1-{[(4R,7S,10S,13S,16S,19R)-19-Amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-L-p rolyl-L-arginylglycinamide;
Nombor CAS	11000-17-2 ;
PubChem CID	644077;
IUPHAR/BPS	2168;
DrugBank	DB00067 ;
ChemSpider	559126 ;
UNII	Y4907O6MFD;
KEGG	D00101 ;
ChEBI	CHEBI:9937 ;
ChEMBL	ChEMBL373742 ;
Data kimia dan fizikal
Formula	C46H65N15O12S2
Jisim molar	1,084.24 g·mol−1
Model 3D (JSmol)	Gambar interaktif;
Ketumpatan	1.6±0.1 g/cm3
	SMILES c1ccc(cc1)C[C@H]2C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)Cc3ccc(cc3)O)N)C(=O)N4CCC[C@H]4C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N;
	InChI InChI=1S/C46H65N15O12S2 /c47-27-22-74-75-23-33(45(73)61-17-5-9-34(61)44(72)56-28(8-4-16-53-46(51)52)39(67)54-21-37(50)65)60-43(71)32(20-36(49)64)59-40(68)29(14-15-35(48)63)55-41(69)31(18-24-6-2-1-3-7-24)58-42(70)30(57-38(27)66)19-25-10-12-26(62)13-11-25/h1-3,6-7,10-13,27-34,62H,4-5,8-9,14-23,47H2,(H2,48,63)(H2,49,64)(H2,50,65)(H,54,67)(H,55,69)(H,56,72)(H,57,66)(H,58,70)(H,59,68)(H,60,71)(H4,51,52,53)/t27-,28-,29-,30-,31-,32-,33-,34-/m0/s1 ; Key:KBZOIRJILGZLEJ-LGYYRGKSSA-N ;

Vasopresin manusia, juga dipanggil hormon antidiuretik (ADH), vasopresin arginina (AVP) atau argipresin,^[4] ialah hormon yang disintesis daripada gen AVP sebagai prohormon peptida dalam neuron di hipotalamus otak,^[5] dan ditukar kepada AVP. Ia kemudian bergerak ke bawah akson yang berakhir di pituitari posterior, dan dilepaskan daripada vesikel ke dalam peredaran sebagai tindak balas kepada hipertonisiti cecair luar sel (hiperosmolaliti). AVP mempunyai dua fungsi utama. Pertama, ia meningkatkan jumlah air tanpa zat terlarut yang diserap kembali ke dalam sistem peredaran daripada turasan dalam tubul ginjal di nefron. Kedua, AVP menyempitkan arteriol lalu meningkatkan rintangan vaskular periferi dan meningkatkan tekanan darah arteri.^[6]^[7]^[8]

Fungsi ketiga adalah mungkin. Sesetengah AVP mungkin dilepaskan terus ke otak dari hipotalamus, dan mungkin memainkan peranan penting dalam tingkah laku sosial, motivasi seksual dan hubungan pasangan, dan tindak balas ibu terhadap tekanan. ^[9]

Vasopressin mendorong pembezaan sel asas menjadi kardiomiosit (sel otot jantung) dan menggalakkan homeostasis otot jantung.^[10]

Ia mempunyai separuh hayat yang sangat singkat, antara 16 dan 24 minit.^[8]

Fisiologi[sunting | sunting sumber]

Vasopresin ialah peptida dengan sembilan asid amino (nonapeptida). Jujukan asid amino vasopresin arginina ialah Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH₂, dengan sisteina membentuk ikatan disulfida, dan glisina terminal C dimodifikasi menjadi amida primer.^[11] Vasopresin lisina (lipresin) mempunyai lisine yang menggantikan arginina di asid amino kelapan, dan terdapat dalam khinzir dan beberapa haiwan berkaitan, manakala vasopresin arginina ditemui pada manusia..^[12]

Struktur oksitosin sangat serupa dengan vasopresin: ia juga merupakan nonapeptida dengan ikatan disulfida, dan urutan asid aminonya berbeza pada dua kedudukan sahaja. Kedua-dua gen tersebut terletak pada kromosom yang sama, dipisahkan oleh jarak yang agak kecil, iaitu kurang daripada 15,000 bes dalam kebanyakan spesies. Sel neurorembesan magnoselular yang merembeskan vasopresin juga berkedudukan bersebelahan dengan neuron magnoselular yang merembeskan oksitosin, dan serupa dalam banyak aspek. Persamaan kedua-dua peptida boleh menyebabkan beberapa tindak balas bersilang: oksitosin mempunyai fungsi antidiuretik yang sedikit, dan tahap AVP yang tinggi boleh menyebabkan pengecutan rahim.^[13]^[14]

Rujukan[sunting | sunting sumber]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000101200 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Anderson DA (2012). Dorland's Illustrated Medical Dictionary (ed. 32nd). Elsevier. ISBN 978-1-4160-6257-8.
^ "Vasopressin and oxytocin gene expression in the human hypothalamus". Journal of Comparative Neurology. 337 (2): 295–306. 1993. doi:10.1002/cne.903370210. PMID 8277003.
^ Marieb E (2014). Anatomy & physiology. Glenview, IL: Pearson Education, Inc. ISBN 978-0-321-86158-0.
^ Caldwell HK, Young WS III (2006). "Oxytocin and Vasopressin: Genetics and Behavioral Implications" (PDF). Dalam Lajtha A, Lim R (penyunting). Handbook of Neurochemistry and Molecular Neurobiology: Neuroactive Proteins and Peptides (ed. 3rd). Berlin: Springer. m/s. 573–607. ISBN 978-0-387-30348-2.
^ ^a ^b "SIADH associated with ciprofloxacin". The Annals of Pharmacotherapy. 47 (10): 1359–63. October 2013. doi:10.1177/1060028013502457. PMID 24259701.
^ "The challenge of translation in social neuroscience: a review of oxytocin, vasopressin, and affiliative behavior". Neuron (dalam bahasa Inggeris). 65 (6): 768–79. March 2010. doi:10.1016/j.neuron.2010.03.005. PMC 2847497. PMID 20346754.
^ "Neurohypophyseal Hormones: Novel Actors of Striated Muscle Development and Homeostasis". review. European Journal of Translational Myology. 24 (3): 3790. September 2014. doi:10.4081/bam.2014.3.217. PMC 4756744. PMID 26913138.
^ Burtis CA, Ashwood ER, Bruns DE (2012). Tietz Textbook of Clinical Chemistry and Molecular Diagnostics (ed. 5th). Elsevier Health Sciences. m/s. 1833. ISBN 978-1-4557-5942-2.
^ Donaldson D (1994). "Polyuria and Disorders of Thirst". Dalam Williams DL, Marks V (penyunting). Scientific Foundations of Biochemistry in Clinical Practice (ed. 2nd). Butterworth-Heinemann. m/s. 76–102. doi:10.1016/B978-0-7506-0167-2.50010-8. ISBN 978-0-7506-0167-2.
^ Li C, Wang W, Summer SN, Westfall TD, Brooks DP, Falk S, Schrier RW (February 2008). "Molecular mechanisms of antidiuretic effect of oxytocin". Journal of the American Society of Nephrology. 19 (2): 225–32. doi:10.1681/ASN.2007010029. PMC 2396735. PMID 18057218.
^ Joo KW, Jeon US, Kim GH, Park J, Oh YK, Kim YS, dll. (October 2004). "Antidiuretic action of oxytocin is associated with increased urinary excretion of aquaporin-2". Nephrology, Dialysis, Transplantation. 19 (10): 2480–6. doi:10.1093/ndt/gfh413. PMID 15280526.

Bacaan lanjut[sunting | sunting sumber]

Rector FC, Brenner BM (2004). Brenner & Rector's the kidney (ed. 7th). Philadelphia: Saunders. ISBN 978-0-7216-0164-9.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000101200 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Dorlands-4] Anderson DA (2012). Dorland's Illustrated Medical Dictionary (ed. 32nd). Elsevier. ISBN 978-1-4160-6257-8.

[Sukhov_1993-5] "Vasopressin and oxytocin gene expression in the human hypothalamus". Journal of Comparative Neurology. 337 (2): 295–306. 1993. doi:10.1002/cne.903370210. PMID 8277003.

[Marieb-6] Marieb E (2014). Anatomy & physiology. Glenview, IL: Pearson Education, Inc. ISBN 978-0-321-86158-0.

[isbn0-387-30348-0-7] Caldwell HK, Young WS III (2006). "Oxytocin and Vasopressin: Genetics and Behavioral Implications" (PDF). Dalam Lajtha A, Lim R (penyunting). Handbook of Neurochemistry and Molecular Neurobiology: Neuroactive Proteins and Peptides (ed. 3rd). Berlin: Springer. m/s. 573–607. ISBN 978-0-387-30348-2.

[babar2013-8] "SIADH associated with ciprofloxacin". The Annals of Pharmacotherapy. 47 (10): 1359–63. October 2013. doi:10.1177/1060028013502457. PMID 24259701.

[9] "The challenge of translation in social neuroscience: a review of oxytocin, vasopressin, and affiliative behavior". Neuron (dalam bahasa Inggeris). 65 (6): 768–79. March 2010. doi:10.1016/j.neuron.2010.03.005. PMC 2847497. PMID 20346754.

[Costa_2014-10] "Neurohypophyseal Hormones: Novel Actors of Striated Muscle Development and Homeostasis". review. European Journal of Translational Myology. 24 (3): 3790. September 2014. doi:10.4081/bam.2014.3.217. PMC 4756744. PMID 26913138.

[11] Burtis CA, Ashwood ER, Bruns DE (2012). Tietz Textbook of Clinical Chemistry and Molecular Diagnostics (ed. 5th). Elsevier Health Sciences. m/s. 1833. ISBN 978-1-4557-5942-2.

[12] Donaldson D (1994). "Polyuria and Disorders of Thirst". Dalam Williams DL, Marks V (penyunting). Scientific Foundations of Biochemistry in Clinical Practice (ed. 2nd). Butterworth-Heinemann. m/s. 76–102. doi:10.1016/B978-0-7506-0167-2.50010-8. ISBN 978-0-7506-0167-2.

[pmid18057218-13] Li C, Wang W, Summer SN, Westfall TD, Brooks DP, Falk S, Schrier RW (February 2008). "Molecular mechanisms of antidiuretic effect of oxytocin". Journal of the American Society of Nephrology. 19 (2): 225–32. doi:10.1681/ASN.2007010029. PMC 2396735. PMID 18057218.

[pmid15280526-14] Joo KW, Jeon US, Kim GH, Park J, Oh YK, Kim YS, dll. (October 2004). "Antidiuretic action of oxytocin is associated with increased urinary excretion of aquaporin-2". Nephrology, Dialysis, Transplantation. 19 (10): 2480–6. doi:10.1093/ndt/gfh413. PMID 15280526.

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