English: For a given dose of semaglutide subcutaneous injection, the drug will accumulate in the blood more after each injection until steady-state is reached. Steady-state is expected to occur between 28 and 35 days of repeat weekly dosing of the same dose. This is directly related to the absorption and elimination rate constants, which are reported to be 0.0286 and 0.00413 (fraction/hour), respectively. The peak and trough plasma concentrations are expected to vary by 30% during steady state (a 30% reduction from peak to trough). A full description of semaglutide can be found here: https://www.youtube.com/watch?v=-3VFB_yolrU