Glukagon

Glukagon
Struktur-struktur sedia ada PDB Pencarian UniProt manusia: PDBe RCSB Senarai kod-kod PDB 1BH0, 1NAU, 2G49, 2M5P, 2M5Q,%%s4ZGM, 4APD, 3IOL, 1D0R,%%s2L64, 2L63
Pengecam-pengecam
Alias	GCG
Pengecam-pengecam luaran	OMIM: 138030 HomoloGene: 136497 GeneCards: GCG
Corak ekspresi RNA Bgee Human Mouse (ortholog) Dizahirkan paling banyak di badan pankreas rektum mukosa jejunum Apendiks Pundi hempedu Duodenum ganglionic eminence Perut fundus badan perut tiada data Rujukan lanjutan untuk data ekspresi BioGPS Rujukan lanjutan untuk data ekspresi
Ontologi gen Fungsi molekul protein binding identical protein binding hormone activity glucagon receptor binding signaling receptor binding Komponen sel Sitoplasma endoplasmic reticulum lumen extracellular region secretory granule lumen Ekstrasel Proses biologi negative regulation of execution phase of apoptosis G protein-coupled receptor signaling pathway regulation of insulin secretion cellular response to glucagon stimulus positive regulation of peptidyl-serine phosphorylation positive regulation of calcium ion import positive regulation of histone H3-K4 methylation positive regulation of peptidyl-threonine phosphorylation feeding behavior positive regulation of ERK1 and ERK2 cascade positive regulation of protein binding cell population proliferation Transduksi isyarat positive regulation of protein kinase activity adenylate cyclase-modulating G protein-coupled receptor signaling pathway protein kinase A signaling positive regulation of insulin secretion involved in cellular response to glucose stimulus response to starvation negative regulation of apoptotic process regulation of signaling receptor activity adenylate cyclase-activating G protein-coupled receptor signaling pathway Sumber:Amigo / QuickGO
Ortolog Spesies Manusia Mencit Entrez 2641 tiadadata Ensembl ENSG00000115263 tiadadata UniProt P01275 tiada data RefSeq (mRNA) NM_002054 tiada data RefSeq (protein) NP_002045 tiada data Kedudukan (UCSC) tiada data tiada data Carian PubMed
Wikidata
Papar/Sunting data manusia

Glukagon ialah suatu hormon polipeptida yang dirembeskan oleh sel pankreas apabila aras glukosa dalam darah adalah rendah, dan mengaktifkan fruktosa 1,6-bisfosfatase melalui kesan penurunannya terhadap aras fruktosa 2,6-bisfosfat. Justeru, glukagon merangsangkan glukoneogenesis dan merencatkan glikolisis di hati. Secara amnya, tindak balas glukagon adalah berlawanan dengan insulin.

Glukagon mengaktifkan enzim adenilat siklase yang memangkinkan pembentukan AMP siklik daripada ATP.

Glukagon hanya bertindak terhadap hati, tetapi tidak terhadap otot.

Lihat juga

• Insulin