Piruvat dehidrogenase fosfatase

Piruvat dehidrogenase fosfatase
Pengecam
Alias	PDP1, PDH, PDP, PDPC, PPM2C, PPM2A, pyruvate dehyrogenase phosphatase catalytic subunit 1, pyruvate dehydrogenase phosphatase catalytic subunit 1
Pengecam-pengecam luaran	OMIM: 605993 MGI: 2685870 HomoloGene: 31928 GeneCards: PDP1
Kedudukan gen (Manusia)
Kr.	Kromosom 8
Tamat	93,926,068 bp
Corak ekspresi RNA
	Top expressed in
	buah lengan; ; Lobus parietal; ; postcentral gyrus; ; kawasan Brodmann 23; ; right ventricle; ; superior frontal gyrus; ; middle temporal gyrus; ; corpus epididymis; ; Ganglion akar dorsal; ; trigeminal ganglion;
	Top expressed in
	lateral geniculate nucleus; ; medial dorsal nucleus; ; medial geniculate nucleus; ; olfactory tubercle; ; primary motor cortex; ; prefrontal cortex; ; piriform cortex; ; Vesikel semen; ; cingulate gyrus; ; habenula;
	More reference expression data
	tiada data
Ontologi gen
Fungsi molekul	protein serine/threonine phosphatase activity; Pengikatan protein plasma; catalytic activity; phosphoprotein phosphatase activity; hydrolase activity; ikatan kation; ikatan ion logam; [pyruvate dehydrogenase (lipoamide) phosphatase activity];
Komponen sel	mitochondrial matrix; Mitokondrion;
Proses biologi	protein dephosphorylation; regulation of acetyl-CoA biosynthetic process from pyruvate; peptidyl-threonine dephosphorylation; positive regulation of pyruvate dehydrogenase activity;
	Sumber:Amigo / QuickGO
Ortolog
	54704
	381511
	ENSG00000164951
	ENSMUSG00000049225
	Q9P0J1
	Q3UV70
	NM_001161778; NM_001161779; NM_001161780; NM_001161781; NM_018444
	NM_001033453; NM_001098230; NM_001098231; NM_001290387; NM_001290391
	NP_001155251; NP_001155252; NP_001155253; NP_060914
	NP_001028625; NP_001091700; NP_001091701; NP_001277316; NP_001277320
	Wikidata
Papar/Sunting data manusia	Papar/Sunting data mencit

Subunit pemangkinan piruvat dehidrogenase fosfatase 1 (PDPC 1) atau fosfatase protein 2C ialah enzim yang dikodkan dalam manusia oleh gen PDP1.^[4]^[5] PDPC 1 ialah enzim yang berfungsi untuk membalikkan kesan piruvat dehidrogenase kinase ke atas piruvat dehidrogenase, sekaligus mengaktifkan piruvat dehidrogenase.

Fungsi[sunting | sunting sumber]

Piruvat dehidrogenase (E1) ialah salah satu daripada tiga komponen (E1, E2 dan E3) dalam kompleks piruvat dehidrogenase yang besar. Piruvat dehidrogenase kinase memangkinkan pemfosforilan di sisa serina E1 untuk menyahaktifkan komponen E1 lalu menghalang kompleks. Piruvat dehidrogenase fosfatase memangkinkan penyahfosforilan dan pengaktifan komponen E1 untuk membalikkan kesan kinase piruvat dehidrogenase kinase.

Piruvat dehidrogenase fosfatase ialah heterodimer yang terdiri daripada pemangkin dan pengawal atur subunit. Dua subunit pemangkin telah dilaporkan; satu terutamanya diekspresikan dalam otot rangka, dan satu lagi lebih banyak dalam hati. Subunit pemangkin yang dikodkan oleh gen ini ialah subunit yang pertama, dan tergolong dalam keluarga fosfatase protein 2C (PP2C). Bersama-sama dengan kompleks piruvat dehidrogenase dan kinase dehidrogenase piruvat, enzim ini terletak dalam matriks mitokondrion.^[4]

Kawal atur[sunting | sunting sumber]

Piruvat dehidrogenase fosfatase dirangsang oleh insulin, PEP dan AMP, tetapi direncat secara persaingan oleh ATP , NADH dan Asetil-KoA.

Rujukan[sunting | sunting sumber]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164951 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: pyruvate dehydrogenase phosphatase catalytic subunit 1".
^ Lawson JE, Niu XD, Browning KS, Trong HL, Yan J, Reed LJ (Sep 1993). "Molecular cloning and expression of the catalytic subunit of bovine pyruvate dehydrogenase phosphatase and sequence similarity with protein phosphatase 2C". Biochemistry. 32 (35): 8987–93. doi:10.1021/bi00086a002. PMID 8396421.

Pautan luar[sunting | sunting sumber]

Pyruvate+Dehydrogenase+Phosphatase dalam Tajuk Subjek Perubatan (MeSH) di Perpustakaan Perubatan Negara AS

Templat:NLM content

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164951 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: pyruvate dehydrogenase phosphatase catalytic subunit 1".

[pmid8396421-5] Lawson JE, Niu XD, Browning KS, Trong HL, Yan J, Reed LJ (Sep 1993). "Molecular cloning and expression of the catalytic subunit of bovine pyruvate dehydrogenase phosphatase and sequence similarity with protein phosphatase 2C". Biochemistry. 32 (35): 8987–93. doi:10.1021/bi00086a002. PMID 8396421.

[1]

[2]

[3]

[4]

[5]