Phillip Allen Sharp

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Phillip Allen Sharp (dilahirkan pada 6 Jun 1944) ialah ahli biologi dan ahli biologi molekul Amerika yang bersama-sama menemui penjalinan RNA. Beliau berkongsi Hadiah Nobel dalam Fisiologi atau Perubatan 1993 bersama Richard J. Roberts untuk "penemuan bahawa gen dalam eukariota bukan rentetan bersambung tetapi mengandungi intron, dan utusan penjalinan RNA untuk memadam intron tersebut boleh terjadi dengan cara yang berbeza, menghasilkan yang berbeza protein dari urutan DNA yang sama".[1][2][3][4][5][6] Beliau telah dipilih untuk menerima Pingat Emas Othmer 2015.[7]

Penerbitan terpilih[sunting | sunting sumber]

  • Petersen C.P.; Bordeleau M.E.; Pelletier J.; Sharp P.A. (17 February 2006). "Short RNAs Repress Translation after Initiation in Mammalian Cells". Mol Cell. 21 (4): 533–42. doi:10.1016/j.molcel.2006.01.031. PMID 16483934. 
  • Tantin D.; Schild-Poulter C.; Wang V.; Hache R.J.; Sharp P.A. (1 December 2005). "The Octamer Binding Transcription Factor Oct-1 is a Stress Sensor". Cancer Res. 65 (23): 10750–8. doi:10.1158/0008-5472.CAN-05-2399. PMID 16322220. 
  • Miskevich F.; Doench J.G.; Townsend M.T.; Sharp P.A.; Constantine-Paton M. (15 April 2006). "RNA Interference of Xenopus NMDAR NR1 in vitro and in vivo". J Neurosci Methods. 152 (1–2): 65–73. doi:10.1016/j.jneumeth.2005.08.010. PMID 16182372. 
  • Hong J.H.; Hwang E.S.; McManus M.T.; Amsterdam A.; Tian Y.; Kalmukova R.; Mueller E.; Benjamin T.; Spiegelman B.M. (12 August 2005). "TAZ, a Transcriptional Modulator of Mesenchymal Stem Cell Differentiation". Science. 309 (5737): 1074–8. doi:10.1126/science.1110955. PMID 16099986. 
  • Johnson D.M.; Yamaji S.; Tennant J.; Srai S.K.; Sharp P.A. (28 March 2005). "Regulation of Divalent Metal Transporter Expression in Human Intestinal Epithelial Cells Following Exposure to Non-haem Iron". FEBS Lett. 579 (9): 1923–9. doi:10.1016/j.febslet.2005.02.035. PMID 15792797. 
  • Neilson J.R.; Sharp P.A. (April 2005). "Herpesviruses Throw a Curve Ball: New Insights into microRNA Biogenesis and Evolution". Nat Methods. 2 (4): 252–4. doi:10.1038/nmeth0405-252. PMID 15782215. 
  • Lee K.B.; Sharp P.A. (7 December 2004). "Transcription-dependent Polyubiquitination of RNA Polymerase II Requires Lysine 63 of Ubiquitin". Biochemistry. 43 (48): 15223–9. doi:10.1021/bi048719x. PMID 15568815. 
  • Mansfield J.H.; Harfe B.D.; Nissen R.; Obenauer J.; Srineel J.; Chaudhuri A.; Farzan-Kashani R.; Zuker M.; Pasquinelli A.E. (October 2004). "MicroRNA-responsive 'Sensor' Transgenes Uncover Hox-like and Other Developmentally Regulated Patterns of Vertebrate MicroRNA Expression". Nat. Genet. 36 (10): 1079–83. doi:10.1038/ng1421. PMID 15361871. 

Rujukan[sunting | sunting sumber]

  1. ^ "The Nobel Prize in Physiology or Medicine 1993". Nobelprize.org. Nobel Media. Dicapai 12 November 2014. 
  2. ^ Sharp, P (2011). "Q&A: Phillip Sharp on biomedical convergence". Cancer Discovery. 1 (5): 370. doi:10.1158/2159-8290.CD-ND11-08. PMID 22586619. 
  3. ^ Musgrave, E (2010). "Advancing science across the disciplines: An interview with Nobel Laureate Phillip A. Sharp, PhD". Clinical and Translational Science. 3 (3): 69–70. doi:10.1111/j.1752-8062.2010.00197.x. PMC 5350715Boleh dicapai secara percuma. PMID 20590673. 
  4. ^ Sharp, P. A.; Sharp, P (2005). "Phillip Sharp discusses RNAi, Nobel Prizes and entrepreneurial science". Drug Discovery Today. 10 (1): 7–10. doi:10.1016/S1359-6446(04)03329-X. PMID 15676292. 
  5. ^ Shampo, M. A.; Kyle, R. A. (2004). "Phillip Sharp--Nobel Prize for discovery of "split genes"". Mayo Clinic Proceedings. 79 (6): 727. doi:10.1016/s0025-6196(11)62621-9. PMID 15182083. 
  6. ^ Raju, T. N. (2000). "The Nobel chronicles. 1993: Richard John Roberts (b 1943) Phillip a Sharp (b 1944)". Lancet. 355 (9220): 2085. doi:10.1016/s0140-6736(05)73547-9. PMID 10885388. 
  7. ^ "Othmer Gold Medal". Science History Institute. Dicapai 4 February 2015.